Hyperpolarized <sup>13</sup>C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma.

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Serval ID
serval:BIB_D02D50659DA6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hyperpolarized <sup>13</sup>C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma.
Journal
Scientific reports
Author(s)
Mishkovsky M., Gusyatiner O., Lanz B., Cudalbu C., Vassallo I., Hamou M.F., Bloch J., Comment A., Gruetter R., Hegi M.E.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
11/03/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
5771
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard imaging techniques. Recent studies demonstrated distinct metabolic profiles of the invasive phenotype in GBM. Magnetic resonance (MR) of hyperpolarized <sup>13</sup> C-labeled probes is a rapidly advancing field that provides real-time metabolic information. Here, we applied hyperpolarized <sup>13</sup> C-glucose MR to mouse GBM models. Compared to controls, the amount of lactate produced from hyperpolarized glucose was higher in the compact GBM model, consistent with the accepted "Warburg effect". However, the opposite response was observed in models reflecting the invasive zone, with less lactate produced than in controls, implying a reduction in aerobic glycolysis. These striking differences could be used to map the metabolic heterogeneity in GBM and to visualize the infiltrative front of GBM.
Pubmed
Web of science
Open Access
Yes
Create date
27/03/2021 17:33
Last modification date
24/04/2021 6:33
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