Induction of the blood-brain barrier specific HT7 and neurothelin epitopes in endothelial cells of the chick chorioallantoic vessels by a soluble factor derived from astrocytes.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_CF040F88C6E7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Induction of the blood-brain barrier specific HT7 and neurothelin epitopes in endothelial cells of the chick chorioallantoic vessels by a soluble factor derived from astrocytes.
Journal
Brain research. Developmental brain research
Author(s)
Lobrinus J.A., Juillerat-Jeanneret L., Darekar P., Schlosshauer B., Janzer R.C.
ISSN
0165-3806 (Print)
ISSN-L
0165-3806
Publication state
Published
Issued date
18/12/1992
Peer-reviewed
Oui
Volume
70
Number
2
Pages
207-211
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Some blood-brain barrier properties of microvascular endothelial cells have been shown to be inducible by astrocytes. We tested the hypothesis that this cellular interaction is mediated by a soluble factor(s). Chick chorioallantoic vessels in ovo were constantly exposed to astrocyte-conditioned medium. We found that endothelial cells exposed to astrocyte-derived factors, but not to glioma- or endothelial cell-derived factors, expressed the HT7 antigen and neurothelin, two specific markers of the blood-brain barrier phenotype. These results indicate that a soluble factor(s) secreted by astrocytes is capable to induce specific blood-brain barrier properties in endothelial cells of non-neural origin.
Keywords
Animals, Antigens, CD, Antigens, Neoplasm, Antigens, Surface, Astrocytes/physiology, Avian Proteins, Basigin, Blood Proteins, Blood-Brain Barrier, Chick Embryo, Endothelium, Vascular/immunology, Epitopes/physiology, Extraembryonic Membranes/blood supply, Gene Expression, Membrane Glycoproteins/metabolism, Rats, Rats, Sprague-Dawley
Pubmed
Web of science
Create date
29/01/2008 19:35
Last modification date
16/07/2020 9:42
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