The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation.

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State: Public
Version: author
Serval ID
serval:BIB_CEB90ED74400
Type
Article: article from journal or magazin.
Collection
Publications
Title
The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation.
Journal
Journal of Neuroscience
Author(s)
Grivel J., Cvetkovic V., Bayer L., Machard D., Tobler I., Mühlethaler M., Serafin M.
ISSN
1529-2401[electronic], 0270-6474[linking]
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
25
Number
16
Pages
4127-4130
Language
english
Notes
Publication types: Comparative Study ; In Vitro ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Sleep deprivation is accompanied by the progressive development of an irresistible need to sleep, a phenomenon whose mechanism has remained elusive. Here, we identified for the first time a reflection of that phenomenon in vitro by showing that, after a short 2 h period of total sleep deprivation, the action of noradrenaline on the wake-promoting hypocretin/orexin neurons changes from an excitation to an inhibition. We propose that such a conspicuous modification of responsiveness should contribute to the growing sleepiness that accompanies sleep deprivation.
Keywords
Animals, Blotting, Northern/methods, Electric Stimulation/methods, Hypothalamus/pathology, Immunohistochemistry/methods, Intracellular Signaling Peptides and Proteins/metabolism, Membrane Potentials/drug effects, Membrane Potentials/physiology, Neurons/drug effects, Neurons/physiology, Neuropeptides/metabolism, Norepinephrine/pharmacology, Patch-Clamp Techniques/methods, RNA, Messenger/biosynthesis, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction/methods, Sleep Deprivation/pathology, Sleep Deprivation/physiopathology, Wakefulness/drug effects, Wakefulness/physiology
Pubmed
Open Access
Yes
Create date
07/03/2011 9:41
Last modification date
20/08/2019 16:49
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