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Article: article from journal or magazin.
The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation.
Journal of Neuroscience
Publication types: Comparative Study ; In Vitro ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Sleep deprivation is accompanied by the progressive development of an irresistible need to sleep, a phenomenon whose mechanism has remained elusive. Here, we identified for the first time a reflection of that phenomenon in vitro by showing that, after a short 2 h period of total sleep deprivation, the action of noradrenaline on the wake-promoting hypocretin/orexin neurons changes from an excitation to an inhibition. We propose that such a conspicuous modification of responsiveness should contribute to the growing sleepiness that accompanies sleep deprivation.
Animals, Blotting, Northern/methods, Electric Stimulation/methods, Hypothalamus/pathology, Immunohistochemistry/methods, Intracellular Signaling Peptides and Proteins/metabolism, Membrane Potentials/drug effects, Membrane Potentials/physiology, Neurons/drug effects, Neurons/physiology, Neuropeptides/metabolism, Norepinephrine/pharmacology, Patch-Clamp Techniques/methods, RNA, Messenger/biosynthesis, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction/methods, Sleep Deprivation/pathology, Sleep Deprivation/physiopathology, Wakefulness/drug effects, Wakefulness/physiology
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