Les inflammasomes et les maladies humaines

Details

Serval ID
serval:BIB_CE87A35951BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Les inflammasomes et les maladies humaines
Journal
Revue de Médecine Interne
Author(s)
Jamilloux Y., Sève P., Henry T.
ISSN
1768-3122 (Electronic)
ISSN-L
0248-8663
Publication state
Published
Issued date
2014
Volume
35
Number
11
Pages
730-741
Language
french
Notes
Inflammasomes in human diseases
Abstract
The understanding of the innate immunity, the first line of the host defence, was significantly modified following the sequential discovery of innate immune receptors such as the Toll-like receptors (TLRs) and the NOD-like receptors (NLRs). In response to recognition of microbial patterns or danger signals, some NLRs assemble a multimolecular platform termed as the inflammasome. Inflammasome assembly leads to the activation of the proinflammatory caspase-1. Consequently, an inflammatory immune response is mounted along with a programmed cell death, called pyroptosis. This review summarizes recent advances in the knowledge of the inflammasome and its role in auto-inflammatory diseases, autoimmune diseases, and most common metabolic, cardiovascular or rheumatic diseases.
Keywords
Inflammasome, Caspase-1, IL-1 beta, Pyroptosis, Auto-inflammatory diseases
Pubmed
Web of science
Create date
05/01/2015 9:32
Last modification date
20/08/2019 15:49
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