Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia
Details
Serval ID
serval:BIB_CE72F5620F9D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia
Journal
Medical and Pediatric Oncology
ISSN
0098-1532 (Print)
Publication state
Published
Issued date
1991
Volume
19
Number
3
Pages
192-8
Language
english
Notes
Case Reports
Journal Article
Review
Journal Article
Review
Abstract
We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid.
Keywords
Antineoplastic Combined Chemotherapy Protocols/administration & dosage/*adverse effects Brain Diseases/*chemically induced/pathology Child Coma/chemically induced Cytarabine/administration & dosage/adverse effects Female Humans Injections, Spinal Leukemia, Lymphocytic, Acute/*drug therapy Methotrexate/administration & dosage/adverse effects Neoplasm Recurrence, Local Paralysis/chemically induced Paraplegia/chemically induced Spinal Cord Diseases/*chemically induced/pathology
Pubmed
Web of science
Create date
25/01/2008 11:35
Last modification date
09/06/2020 6:21
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