Recurrent febrile panniculitis and hepatitis in two patients with acquired complement deficiency and paraproteinemia

Details

Serval ID
serval:BIB_CDFCAF324EB7
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Recurrent febrile panniculitis and hepatitis in two patients with acquired complement deficiency and paraproteinemia
Journal
American Journal of Medicine
Author(s)
Pascual  M., Widmann  J. J., Schifferli  J. A.
ISSN
0002-9343
Publication state
Published
Issued date
11/1987
Peer-reviewed
Oui
Volume
83
Number
5
Pages
959-62
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
Repeated episodes of febrile panniculitis and hepatitis were the main clinical features in two patients with an IgG1 kappa paraproteinemia and severe depletion of the early components of the classical pathway of complement (acquired C1 inhibitor deficiency). They did not have episodes of cutaneous angioedema or evidence of immune complex disease. In the more severely affected patient, the episodes responded to steroids. These features have not been described with acquired C1 inhibitor deficiency and may be related to complement activation.
Keywords
Complement Activation Complement C1 Inactivator Proteins/*deficiency Hepatitis/*immunology Humans Immunoglobulin kappa-Chains/*immunology Male Middle Aged Panniculitis, Nodular Nonsuppurative/*immunology Paraproteinemias/*immunology Recurrence
Pubmed
Web of science
Create date
29/01/2008 13:52
Last modification date
20/08/2019 15:48
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