Markers for sepsis diagnosis in the forensic setting: state of the art.

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State: Public
Version: Final published version
Serval ID
serval:BIB_CCFE5F29591E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Markers for sepsis diagnosis in the forensic setting: state of the art.
Journal
Croatian Medical Journal
Author(s)
Palmiere C., Augsburger M.
ISSN
1332-8166 (Electronic)
ISSN-L
0353-9504
Publication state
Published
Issued date
2014
Volume
55
Number
2
Pages
103-114
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Reliable diagnoses of sepsis remain challenging in forensic pathology routine despite improved methods of sample collection and extensive biochemical and immunohistochemical investigations. Macroscopic findings may be elusive and have an infectious or non-infectious origin. Blood culture results can be difficult to interpret due to postmortem contamination or bacterial translocation. Lastly, peripheral and cardiac blood may be unavailable during autopsy. Procalcitonin, C-reactive protein, and interleukin-6 can be measured in biological fluids collected during autopsy and may be used as in clinical practice for diagnostic purposes. However, concentrations of these parameters may be increased due to etiologies other than bacterial infections, indicating that a combination of biomarkers could more effectively discriminate non-infectious from infectious inflammations. In this article, we propose a review of the literature pertaining to the diagnostic performance of classical and novel biomarkers of inflammation and bacterial infection in the forensic setting.
Pubmed
Web of science
Create date
30/04/2014 13:25
Last modification date
20/08/2019 15:47
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