Targeting endoplasmic reticulum signaling pathways in cancer.

Details

Serval ID
serval:BIB_CC94D4E9246F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Targeting endoplasmic reticulum signaling pathways in cancer.
Journal
Acta Oncologica
Author(s)
Martinon F.
ISSN
1651-226X (Electronic)
ISSN-L
0284-186X
Publication state
Published
Issued date
2012
Volume
51
Number
7
Pages
822-830
Language
english
Abstract
The endoplasmic reticulum (ER) orchestrates the production of membrane-bound and secreted proteins. However, its capacity to process the synthesis and folding of protein is limited. Protein overload and the accumulation of misfolded proteins in the ER trigger an adaptive response known as the ER-stress response that is mediated by specific ER-anchored signaling pathways. This response regulates cell functions aimed at restoring cellular homeostasis or at promoting apoptosis of irreparably damaged cells. Activation or deregulation of ER-signaling pathways has been associated with various diseases including cancer. Here we discuss how tumors engage ER-signaling pathways to promote tumorigenesis and how manipulation of this process by anticancer drugs may contribute to cancer treatment.
Pubmed
Web of science
Create date
07/12/2012 10:39
Last modification date
20/08/2019 15:47
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