Cohort profile: the Swiss HIV Cohort study.

Details

Serval ID
serval:BIB_CC58424DBFA3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cohort profile: the Swiss HIV Cohort study.
Journal
International Journal of Epidemiology
Author(s)
Schoeni-Affolter F., Schoeni-Affolter F., Ledergerber B., Rickenbach M., Rudin C., Günthard H.F., Telenti A., Furrer H., Yerly S., Francioli P.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Aebi C., Battegay M., Bernasconi E., Boffi El Amari E., Böni J., Brazzola P., Bucher HC., Bürgisser P., Calmy A., Cavassini M., Cheseaux JJ., Drack G., Dubs R., Egger M., Elzi L., Fischer M., Flepp M., Fontana A., Francioli P., Furrer H., Fux CA., Gerber S., Gorgievski M., Grawe C., Günthard HF., Gyr T., Hirsch HH., Hirschel B., Hösli I., Kaiser L., Kahlert C., Karrer U., Kind C., Klimkait T., Ledergerber B., Martinetti G., Martinez de Tejada B., Müller N., Nadal D., Paccaud F., Pantaleo G., Raio L., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., Weber R., Wyler CA., Yerly S.
ISSN
1464-3685 (Electronic)
ISSN-L
0300-5771
Publication state
Published
Issued date
2010
Volume
39
Number
5
Pages
1179-1189
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The substantial recurrence rate of colorectal cancer following potentially curative resection has fuelled the search for effective adjuvant therapy. Previous trials using 5-fluorouracil (5-FU) as a single agent or in combination chemotherapy regimens have not demonstrated meaningful benefits, an impression reflected in the results of a meta-analysis encompassing large patient numbers. Newer developments utilizing intraportal chemotherapy and the combination of 5-FU and levamisole have resulted in lower recurrence rates and improved survival in patients with colon cancer. In advanced disease, the biochemical modulation of 5-FU by Leucovorin has been shown to prolong survival in some studies. Combined chemotherapy and radiotherapy or chemotherapy alone have showed promising results in rectal cancer. These developments have now been incorporated into ongoing trials.
Keywords
Adolescent, Adult, Aged, Aging, Anti-Retroviral Agents/therapeutic use, Antiretroviral Therapy, Highly Active, Female, HIV Infections/drug therapy, HIV Infections/epidemiology, Health Behavior, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Middle Aged, Multicenter Studies as Topic, Patient Dropouts, Pregnancy, Pregnancy Complications, Infectious/drug therapy, Pregnancy Complications, Infectious/epidemiology, Prospective Studies, Socioeconomic Factors, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
29/12/2010 15:38
Last modification date
20/08/2019 15:47
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