Cohort profile: the Swiss HIV Cohort study.

Détails

ID Serval
serval:BIB_CC58424DBFA3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cohort profile: the Swiss HIV Cohort study.
Périodique
International Journal of Epidemiology
Auteur(s)
Schoeni-Affolter F., Schoeni-Affolter F., Ledergerber B., Rickenbach M., Rudin C., Günthard H.F., Telenti A., Furrer H., Yerly S., Francioli P.
Collaborateur(s)
Swiss HIV Cohort Study
Contributeur(s)
Aebi C., Battegay M., Bernasconi E., Boffi El Amari E., Böni J., Brazzola P., Bucher HC., Bürgisser P., Calmy A., Cavassini M., Cheseaux JJ., Drack G., Dubs R., Egger M., Elzi L., Fischer M., Flepp M., Fontana A., Francioli P., Furrer H., Fux CA., Gerber S., Gorgievski M., Grawe C., Günthard HF., Gyr T., Hirsch HH., Hirschel B., Hösli I., Kaiser L., Kahlert C., Karrer U., Kind C., Klimkait T., Ledergerber B., Martinetti G., Martinez de Tejada B., Müller N., Nadal D., Paccaud F., Pantaleo G., Raio L., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., Weber R., Wyler CA., Yerly S.
ISSN
1464-3685 (Electronic)
ISSN-L
0300-5771
Statut éditorial
Publié
Date de publication
2010
Volume
39
Numéro
5
Pages
1179-1189
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The substantial recurrence rate of colorectal cancer following potentially curative resection has fuelled the search for effective adjuvant therapy. Previous trials using 5-fluorouracil (5-FU) as a single agent or in combination chemotherapy regimens have not demonstrated meaningful benefits, an impression reflected in the results of a meta-analysis encompassing large patient numbers. Newer developments utilizing intraportal chemotherapy and the combination of 5-FU and levamisole have resulted in lower recurrence rates and improved survival in patients with colon cancer. In advanced disease, the biochemical modulation of 5-FU by Leucovorin has been shown to prolong survival in some studies. Combined chemotherapy and radiotherapy or chemotherapy alone have showed promising results in rectal cancer. These developments have now been incorporated into ongoing trials.
Mots-clé
Adolescent, Adult, Aged, Aging, Anti-Retroviral Agents/therapeutic use, Antiretroviral Therapy, Highly Active, Female, HIV Infections/drug therapy, HIV Infections/epidemiology, Health Behavior, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Middle Aged, Multicenter Studies as Topic, Patient Dropouts, Pregnancy, Pregnancy Complications, Infectious/drug therapy, Pregnancy Complications, Infectious/epidemiology, Prospective Studies, Socioeconomic Factors, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/12/2010 16:38
Dernière modification de la notice
09/05/2019 1:20
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