IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_CC1A2AB80EDD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells.
Journal
Cell Reports
Author(s)
Dubey L.K., Ludewig B., Luther S.A. (co-last), Harris N.L.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
21/05/2019
Peer-reviewed
Oui
Volume
27
Number
8
Pages
2442-2458.e5
Language
english
Abstract
Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5 <sup>+</sup> dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting CXCR5 <sup>+</sup> dendritic cells has remained unclear. Using multiplex imaging combined with deep tissue analysis, we observed new CXCL13 <sup>+</sup> fibroblastic reticular cells surrounding paracortical and cortical B cell follicles in the mLNs of infected mice. CXCL13 <sup>+</sup> fibroblasts expressed markers of marginal reticular cells (MRCs), and their expansion required lymphotoxin (LT)-dependent interactions between IL-4Rα-expressing B cells and CCL19 <sup>+</sup> fibroblasts. Infection-induced follicles did not necessarily contain follicular dendritic cells (FDCs), indicating that CXCL13 <sup>+</sup> fibroblasts may instead drive their formation. These data reveal a role for lymphotoxin signaling to CCL19 <sup>+</sup> fibroblasts in the development of CXCL13 <sup>+</sup> MRC-like cells and adaptive type 2 immunity in response to helminth infection.
Keywords
CXCL13, Heligmosomoides polygyrus, IL-4Rα, MAdCAM-1, fibroblastic reticular cells, helminth infection, interfollicular region, intestinal infection, marginal reticular cells, mesenteric lymph node
Pubmed
Web of science
Open Access
Yes
Create date
25/05/2019 10:41
Last modification date
21/11/2022 9:24
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