Regulation of protective immunity against Leishmania major in mice.

Details

Serval ID
serval:BIB_CC10C6047D11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Regulation of protective immunity against Leishmania major in mice.
Journal
Current Opinion in Immunology
Author(s)
Louis J., Himmelrich H., Parra-Lopez C., Tacchini-Cottier F., Launois P.
ISSN
0952-7915 (Print)
ISSN-L
0952-7915
Publication state
Published
Issued date
1998
Volume
10
Number
4
Pages
459-464
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Resolution of lesions induced by Leishmania major in mice results from the development of Th1 responses. Cytokines produced by Th1 cells activate macrophages to a parasiticidal state. The development of Th2 responses in mice from a few strains underlies susceptibility to infection. Cytokines produced by Th2 cells exacerbate the development of lesions because of their deactivating properties for macrophages. This murine model of infection has provided significant insight into the mechanisms intrinsic to the differentiation of disparate CD4+ T cell subsets in vivo in animals from different genetic backgrounds.
Keywords
Animals, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/immunology, Cell Differentiation, Disease Susceptibility, Immunity, Innate, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Leishmaniasis, Cutaneous/prevention & control, Mice
Pubmed
Web of science
Create date
24/01/2008 16:09
Last modification date
20/08/2019 16:46
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