Hippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.

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State: Public
Version: author
Serval ID
serval:BIB_CBE44BB9009D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.
Journal
Psychiatry Research
Author(s)
Prestia A., Boccardi M., Galluzzi S., Cavedo E., Adorni A., Soricelli A., Bonetti M., Geroldi C., Giannakopoulos P., Thompson P., Frisoni G.
ISSN
0165-1781 (Print)
ISSN-L
0165-1781
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
192
Number
2
Pages
77-83
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Patients with Alzheimer's disease (AD) and schizophrenia display cognitive, behavioural disturbances and morphological abnormalities. Although these latter reflect progressive neurodegeneration in AD, their significance in schizophrenia is still unclear. We explored the patterns of hippocampal and amygdalar atrophy in those patients and their associations with clinical parameters. Structural magnetic resonance imaging was performed in 20 elderly schizophrenia patients, 20 AD and 19 healthy older controls. Hippocampal and amygdalar volumes were obtained by manual segmentation with a standardized protocol and compared among groups. In both schizophrenia and AD patients, left hippocampal and amygdalar volumes were significantly smaller. The hippocampus/amygdala ratio was significantly lower in schizophrenia compared to both AD cases [2.4 bilaterally, 95% C.I. 2.2 to 2.7] and healthy controls bilaterally [2.5, 95% C.I. 2.3 to 2.9 in left and 2.7, 95% C.I. 2.4 to 3.1 in right hemisphere]. In schizophrenia patients, a significant positive correlation was found between age at disease onset and the right hippocampus/amygdala volume ratio (Spearman rho=0.56). Negative symptoms correlated with higher right/left amygdala volume ratio (Spearman's rho=0.43). Our data show that unlike AD, the hippocampus/amygdala ratio is abnormally low and correlates with the age at onset in schizophrenia, being a neurodevelopmental signature of the disease.
Pubmed
Web of science
Create date
16/05/2011 13:36
Last modification date
20/08/2019 16:46
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