Un guide pratique au traitement des gliomes [A practical guide for the management of gliomas]

Details

Serval ID
serval:BIB_CB9BE167BD46
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Un guide pratique au traitement des gliomes [A practical guide for the management of gliomas]
Journal
Bulletin du cancer
Author(s)
Stupp R., Pica A., Mirimanoff R.O., Michielin O.
ISSN
1769-6917[electronic]
Publication state
Published
Issued date
2007
Volume
94
Number
9
Pages
817-22
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review - Publication Status: ppublish
Abstract
The management of gliomas in daily clinical practice is challenging. It requires a multidisciplinary and coordinated approach involving neurosurgery, radiotherapy and, finally, chemotherapy. Important progress has been made during the last years with the introduction of a combined treatment associating standard radiotherapy with concomitant chemotherapy using temozolomide, a novel alkylating agent. For the first time in many years a new treatment strategy translated into a significant prolongation of survival. In parallel, molecular markers (e.g. loss of heterozygosity on chromosomes 1p and 19q or methylation of the methyl-guanine methyl transferase [MGMT] gene promoter) allowed for identification of distinct subtypes of glioma or prediction of treatment response. In this "Practical Guide", we describe the daily practice and aim at answering some common questions in the management of patients suffering from glioblastoma, astrocytoma, oligodendroglioma and low grade glioma. The therapeutic options presented here are based on evidences from the literature. In the absence of documented evidence, the empirical choices from our local practice are explained and justified.
Keywords
Central Nervous System Neoplasms, Clinical Trials as Topic, Combined Modality Therapy, Disease Management, Glioma, Humans, Treatment Outcome
Pubmed
Web of science
Create date
28/01/2008 12:22
Last modification date
20/08/2019 16:46
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