Effects of beta-blockade on energy metabolism following burns.

Details

Serval ID
serval:BIB_CB932BCDBB3F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of beta-blockade on energy metabolism following burns.
Journal
Burns
Author(s)
Breitenstein E., Chioléro R.L., Jéquier E., Dayer P., Krupp S., Schutz Y.
ISSN
0305-4179 (Print)
ISSN-L
0305-4179
Publication state
Published
Issued date
1990
Volume
16
Number
4
Pages
259-264
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The purpose of this study was to compare the effects of propranolol administered either by i.v. infusion or by prolonged oral administration (4 days) during the first 3 weeks following burns. The resting metabolic rate (RMR) of 10 non-infected fasting burned patients (TBSA: 28 per cent, range 18-37 per cent) was determined four times consecutively by indirect calorimetry (open circuit hood system) following: (1) i.v. physiological saline; (2) i.v. propranolol infusion (2 micrograms/kg/min following a bolus of 80 micrograms/kg); (3) oral propranolol (40 mg q.i.d. during 4 +/- 1 days); and (4) in control patients. All patients showed large increases in both RMR (144 +/- 2 per cent of reference values) and in urinary catecholamine excretion (three to four times as compared to control values). The infusion of propranolol induced a significant decrease in RMR to 135 +/- 2 per cent and oral propranolol to 129 +/- 3 per cent of reference values. A decrease in lipid oxidation but no change in carbohydrate and protein oxidation were observed during propranolol administration. It is concluded that the decrease in RMR induced by propranolol was not influenced by the route of administration. The magnitude of the decrease in energy expenditure suggests that beta-adrenergic hyperactivity represents only one of the mediators of the hypermetabolic response to burn injury.
Keywords
Administration, Oral, Adult, Body Weight/drug effects, Burns/metabolism, Catecholamines/urine, Energy Metabolism/drug effects, Female, Heart Rate/drug effects, Humans, Injections, Intravenous, Lipid Metabolism, Male, Middle Aged, Propranolol/administration & dosage, Propranolol/blood
Pubmed
Web of science
Create date
21/01/2008 13:08
Last modification date
20/08/2019 15:46
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