Antidepressants for the treatment of chronic pain.

Details

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State: Public
Version: author
Serval ID
serval:BIB_CB3ECEE27130
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Antidepressants for the treatment of chronic pain.
Journal
Drugs
Author(s)
Verdu B., Decosterd I., Buclin T., Stiefel F., Berney A.
ISSN
0012-6667
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
68
Number
18
Pages
2611-2632
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review SAPHIRID:76035
Abstract
Chronic pain represents one of the most important public health problems and, in addition to classical analgesics, antidepressants are an essential part of the therapeutic strategy. This article reviews available evidence on the efficacy and safety of antidepressants in major chronic pain conditions; namely, neuropathic pain, headaches, low back pain, fibromyalgia, irritable bowel syndrome (IBS) and cancer pain. Studies, reviews and meta-analyses published from 1991 to March 2008 were retrieved through MEDLINE, PsycINFO and the Cochrane database using numerous key words for pain and antidepressants. In summary, evidence supports the use of tricyclic antidepressants in neuropathic pain, headaches, low back pain, fibromyalgia and IBS. The efficacy of the newer serotonin and norepinephrine reuptake inhibitors is less supported by evidence, but can be recommended in neuropathic pain, migraines and fibromyalgia. To date, evidence does not support an analgesic effect of serotonin reuptake inhibitors, but beneficial effects on well-being were reported in several chronic pain conditions. These results are discussed in the light of current insights in the neurobiology of pain, the reciprocal relationship between pain and depression, and future developments in this field of research.
Keywords
Animals, Antidepressive Agents, Chronic Disease, Databases as Topic, Humans, Models, Theoretical, Pain, Randomized Controlled Trials as Topic, Treatment Outcome
Pubmed
Web of science
Create date
08/01/2009 9:56
Last modification date
20/08/2019 16:46
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