Fatal flecainide intoxication.

Details

Serval ID
serval:BIB_CAD9862B946B
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Fatal flecainide intoxication.
Journal
Forensic Science International
Author(s)
Romain N., Giroud C., Michaud K., Augsburger M., Mangin P.
ISSN
0379-0738
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
106
Number
2
Pages
115-123
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
A fatal case attributed to flecainide acetate (Tambocor), a class Ic antiarrythmic drug, is presented. Flecainide was detected by GC/MS in gastric contents, blood and liver as well. The urine analysis revealed the presence of its dealkylated metabolite. Body fluids and tissue concentrations determined by GC/ECD were 7.7 mg/kg in femoral blood, 0.26 mg/kg in bile, 18 mg/kg in liver, 0.17 mg/kg in cerebrospinal fluid, 0.22 mg/kg in brain cortex and 28.9 mg/kg in urine. The total amount of flecainide in gastric contents was about 43 mg. Even taking into account the postmortem redistribution of flecainide, its blood level still remains in the toxic range.
Keywords
Aged, Anti-Arrhythmia Agents, Bile, Body Fluids, Cerebral Cortex, Fatal Outcome, Flecainide, Gas Chromatography-Mass Spectrometry, Gastrointestinal Contents, Humans, Liver, Male, Overdose, Suicide, Tissue Distribution
Pubmed
Web of science
Create date
08/02/2008 18:44
Last modification date
20/08/2019 16:45
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