miRNA-mediated crosstalk between transcripts: The missing "linc"?

Details

Serval ID
serval:BIB_CA9289D0481D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
miRNA-mediated crosstalk between transcripts: The missing "linc"?
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Author(s)
Tan J.Y., Marques A.C.
ISSN
1521-1878 (Electronic)
ISSN-L
0265-9247
Publication state
Published
Issued date
03/2016
Peer-reviewed
Oui
Volume
38
Number
3
Pages
295-301
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Recently, transcriptome-wide sequencing data have revealed the pervasiveness of intergenic long noncoding RNA (lncRNA) transcription. Subsets of lncRNAs have been demonstrated to crosstalk with and post-transcriptionally regulate mRNAs in a microRNA (miRNA)-dependent manner. Referred to as long noncoding competitive endogenous RNAs (lnceRNAs), these transcripts can contribute to diverse aspects of organismal and cellular biology, likely by providing a hitherto unrecognized layer of gene expression regulation. Here, we discuss the biological relevance of post-transcriptional regulation by lnceRNAs, provide insights on recent advances in the understanding of lnceRNA regulatory networks, and speculate on molecular factors that facilitate miRNA-dependent crosstalk between lnceRNAs and other transcripts.

Keywords
Animals, Humans, MicroRNAs/physiology, RNA Interference, RNA, Messenger/genetics, RNA, Messenger/metabolism, Transcription, Genetic
Pubmed
Create date
16/02/2016 18:21
Last modification date
20/08/2019 16:45
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