Critical single proximal left arterial descending coronary artery stenosis to mimic chronic myocardial ischemia: a new model induced by minimal invasive technology.

Details

Serval ID
serval:BIB_CA52AB3910E8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Critical single proximal left arterial descending coronary artery stenosis to mimic chronic myocardial ischemia: a new model induced by minimal invasive technology.
Journal
Journal of Vascular Research
Author(s)
Horstick G., Bierbach B., Abegunewardene N., Both S., Kuhn S., Manefeld D., Reinecke H.J., Vosseler M., Helisch A., Becker D., Lauterbach M., Kempski O., Lehr H.A.
ISSN
1423-0135[electronic], 1018-1172[linking]
Publication state
Published
Issued date
2009
Volume
46
Number
4
Pages
290-298
Language
english
Abstract
BACKGROUND/AIMS: The present report examines a new pig model for progressive induction of high-grade stenosis, for the study of chronic myocardial ischemia and the dynamics of collateral vessel growth. METHODS: Thirty-nine Landrace pigs were instrumented with a novel experimental stent (GVD stent) in the left anterior descending coronary artery. Eight animals underwent transthoracic echocardiography at rest and under low-dose dobutamine. Seven animals were examined by nuclear PET and SPECT analysis. Epi-, mid- and endocardial fibrosis and the numbers of arterial vessels were examined by histology. RESULTS: Functional analysis showed a significant decrease in global left ventricular ejection fraction (24.5 +/- 1.6%) 3 weeks after implantation. There was a trend to increased left ventricular ejection fraction after low-dose dobutamine stress (36.0 +/- 6.6%) and a significant improvement of the impaired regional anterior wall motion. PET and SPECT imaging documented chronic hibernation. Myocardial fibrosis increased significantly in the ischemic area with a gradient from epi- to endocardial. The number of arterial vessels in the ischemic area increased and coronary angiography showed abundant collateral vessels of Rentrop class 1. CONCLUSION: The presented experimental model mimics the clinical situation of chronic myocardial ischemia secondary to 1-vessel coronary disease.
Keywords
Angioplasty, Transluminal, Percutaneous Coronary/adverse effects, Angioplasty, Transluminal, Percutaneous Coronary/instrumentation, Animals, Chronic Disease, Collateral Circulation, Coronary Angiography, Coronary Circulation, Coronary Stenosis/complications, Coronary Stenosis/diagnosis, Coronary Vessels/pathology, Coronary Vessels/physiopathology, Critical Illness, Disease Models, Animal, Echocardiography, Stress, Female, Fibrosis, Male, Myocardial Ischemia/diagnosis, Myocardial Ischemia/etiology, Positron-Emission Tomography, Severity of Illness Index, Stents/adverse effects, Stroke Volume, Swine, Time Factors, Tomography, Emission-Computed, Single-Photon, Ventricular Dysfunction, Left/etiology, Ventricular Dysfunction, Left/physiopathology
Pubmed
Web of science
Open Access
Yes
Create date
20/05/2009 20:30
Last modification date
20/08/2019 16:45
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