cFLIP regulation of lymphocyte activation and development

Details

Serval ID
serval:BIB_C9272FC055BC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
cFLIP regulation of lymphocyte activation and development
Journal
Nature Reviews. Immunology
Author(s)
Budd  R. C., Yeh  W. C., Tschopp  J.
ISSN
1474-1733 (Print)
Publication state
Published
Issued date
03/2006
Volume
6
Number
3
Pages
196-204
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Abstract
Cellular caspase-8 (FLICE)-like inhibitory protein (cFLIP) was originally identified as an inhibitor of death-receptor signalling through competition with caspase-8 for recruitment to FAS-associated via death domain (FADD). More recently, it has been determined that both cFLIP and caspase-8 are required for the survival and proliferation of T cells following T-cell-receptor stimulation. This paradoxical finding launched new investigations of how these molecules might connect with signalling pathways that link to cell survival and growth following antigen-receptor activation. As discussed in this Review, insight gained from these studies indicates that cFLIP and caspase-8 form a heterodimer that ultimately links T-cell-receptor signalling to activation of nuclear factor-kappaB through a complex that includes B-cell lymphoma 10 (BCL-10), mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1) and receptor-interacting protein 1 (RIP1).
Keywords
Animals Antigens, CD95/physiology Autoimmunity CASP8 and FADD-Like Apoptosis Regulating Protein Humans Intracellular Signaling Peptides and Proteins/chemistry/genetics/*physiology *Lymphocyte Activation Neoplasms/etiology T-Lymphocytes/immunology/*physiology
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 15:44
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