cFLIP regulation of lymphocyte activation and development
Détails
ID Serval
serval:BIB_C9272FC055BC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
cFLIP regulation of lymphocyte activation and development
Périodique
Nature Reviews. Immunology
ISSN
1474-1733 (Print)
Statut éditorial
Publié
Date de publication
03/2006
Volume
6
Numéro
3
Pages
196-204
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Résumé
Cellular caspase-8 (FLICE)-like inhibitory protein (cFLIP) was originally identified as an inhibitor of death-receptor signalling through competition with caspase-8 for recruitment to FAS-associated via death domain (FADD). More recently, it has been determined that both cFLIP and caspase-8 are required for the survival and proliferation of T cells following T-cell-receptor stimulation. This paradoxical finding launched new investigations of how these molecules might connect with signalling pathways that link to cell survival and growth following antigen-receptor activation. As discussed in this Review, insight gained from these studies indicates that cFLIP and caspase-8 form a heterodimer that ultimately links T-cell-receptor signalling to activation of nuclear factor-kappaB through a complex that includes B-cell lymphoma 10 (BCL-10), mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1) and receptor-interacting protein 1 (RIP1).
Mots-clé
Animals
Antigens, CD95/physiology
Autoimmunity
CASP8 and FADD-Like Apoptosis Regulating Protein
Humans
Intracellular Signaling Peptides and
Proteins/chemistry/genetics/*physiology
*Lymphocyte Activation
Neoplasms/etiology
T-Lymphocytes/immunology/*physiology
Pubmed
Web of science
Création de la notice
24/01/2008 16:19
Dernière modification de la notice
20/08/2019 16:44