Neuron death in the developing avian isthmo-optic nucleus, and its relation to the establishment of functional circuitry.

Details

Serval ID
serval:BIB_C891689A0E9E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Neuron death in the developing avian isthmo-optic nucleus, and its relation to the establishment of functional circuitry.
Journal
Journal of Neurobiology
Author(s)
Clarke P.G.H.
ISSN
0022-3034[print], 0022-3034[linking]
Publication state
Published
Issued date
1992
Volume
23
Number
9
Pages
1140-1158
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review Comparative Study Journal Article Research Support, Non-U.S. Gov't Review --- Old month value: Nov
Abstract
The present review covers all the published data on neuron death in the developing avian isthmo-optic nucleus (ION), which provides a particularly convenient situation for studying the causes and consequences of neuron death in the development of the vertebrate central nervous system. The main conclusions are as follows: The naturally occurring neuron death in the ION is related both temporally and causally to the ION's formation of afferent and efferent connections. The ION neurons need to obtain both anterograde and retrograde survival signals in order to survive during a critical period in embryogenesis. They may compete, at least for the retrograde signals, but the nature of the competition is still unclear. The retrograde signals are modified by action potentials. Neurons dying from a lack of anterograde survival signals can be distinguished morphologically from ones dying from a lack of retrograde signals. The neuron death refines circuitry by selectively eliminating neurons with "aberrant" axons projecting to the "wrong" (i.e., ipsilateral) retina or to the "wrong" (topographically inappropriate) part of the contralateral retina.
Keywords
Animals, Axons/physiology, Cell Death/physiology, Chick Embryo, Efferent Pathways/cytology, Efferent Pathways/embryology, Neurons/cytology, Retina/embryology, Retina/physiology
Pubmed
Web of science
Create date
20/01/2008 18:49
Last modification date
20/08/2019 16:43
Usage data