Epigenetic regulation of the bacterial cell cycle.

Details

Serval ID
serval:BIB_C83FABFCF4E1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Epigenetic regulation of the bacterial cell cycle.
Journal
Current Opinion in Microbiology
Author(s)
Collier J.
ISSN
1879-0364[electronic], 1369-5274[linking]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
12
Number
6
Pages
722-729
Language
english
Abstract
N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cycle. DNA adenine methylation is mediated by Dam in gamma-proteobacteria and by CcrM in alpha-proteobacteria. A major difference between them is that CcrM is cell cycle regulated, while Dam is active throughout the cell cycle. In alpha-proteobacteria, GANTC sites can remain hemi-methylated for a significant period of the cell cycle, depending on their location on the chromosome. In gamma-proteobacteria, most GATC sites are only transiently hemi-methylated, except regulatory GATC sites that are protected from Dam methylation by specific DNA-binding proteins.
Keywords
Adenine/analogs & derivatives, Adenine/metabolism, Alphaproteobacteria/physiology, Bacterial Proteins/metabolism, Cell Cycle, DNA, Bacterial/metabolism, Epigenesis, Genetic, Gammaproteobacteria/physiology, Gene Expression Regulation, Bacterial, Protein Binding, Site-Specific DNA-Methyltransferase (Adenine-Specific)/metabolism, Transcription Factors/metabolism
Pubmed
Web of science
Create date
19/11/2009 11:31
Last modification date
20/08/2019 16:43
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