Simultaneous topography-guided photorefractive keratectomy followed by corneal collagen cross-linking for keratoconus.
Details
Serval ID
serval:BIB_C692731B64A3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Simultaneous topography-guided photorefractive keratectomy followed by corneal collagen cross-linking for keratoconus.
Journal
American journal of ophthalmology
ISSN
1879-1891 (Electronic)
ISSN-L
0002-9394
Publication state
Published
Issued date
11/2011
Peer-reviewed
Oui
Volume
152
Number
5
Pages
748-755
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To present the long-term results after simultaneous photorefractive keratectomy followed by corneal collagen cross-linking for keratoconus.
Prospective, interventional, consecutive case series.
In this study, 26 patients (31 eyes) with progressive keratoconus were included. All patients underwent customized topography-guided photorefractive keratectomy immediately followed by corneal collagen cross-linking with the use of riboflavin and ultraviolet A irradiation. Epithelium was removed by transepithelial phototherapeutic keratectomy in all cases.
Mean follow-up was 19.53 ± 3.97 months (range, 12 to 25 months). Mean preoperative spherical equivalent was -2.3 ± 2.8 diopters (D), whereas at the last follow-up examination, it was significantly (P < .001) reduced to -1.08 ± 2.41 D. Logarithm of the minimal angle of resolution uncorrected and best-corrected visual acuity were reduced significantly by 0.46 and 0.084 (P < .001), respectively, at the last follow-up examination. Finally, mean steep and flat keratometry readings were reduced by 2.35 (P < .001) and 1.18 (P = .013) at the last follow-up examination.
Simultaneous photorefractive keratectomy followed by corneal collagen cross-linking seems to be a promising treatment alternative in our series of keratoconic patients.
Prospective, interventional, consecutive case series.
In this study, 26 patients (31 eyes) with progressive keratoconus were included. All patients underwent customized topography-guided photorefractive keratectomy immediately followed by corneal collagen cross-linking with the use of riboflavin and ultraviolet A irradiation. Epithelium was removed by transepithelial phototherapeutic keratectomy in all cases.
Mean follow-up was 19.53 ± 3.97 months (range, 12 to 25 months). Mean preoperative spherical equivalent was -2.3 ± 2.8 diopters (D), whereas at the last follow-up examination, it was significantly (P < .001) reduced to -1.08 ± 2.41 D. Logarithm of the minimal angle of resolution uncorrected and best-corrected visual acuity were reduced significantly by 0.46 and 0.084 (P < .001), respectively, at the last follow-up examination. Finally, mean steep and flat keratometry readings were reduced by 2.35 (P < .001) and 1.18 (P = .013) at the last follow-up examination.
Simultaneous photorefractive keratectomy followed by corneal collagen cross-linking seems to be a promising treatment alternative in our series of keratoconic patients.
Keywords
Adult, Collagen/metabolism, Combined Modality Therapy, Corneal Stroma/metabolism, Corneal Topography, Cross-Linking Reagents, Female, Follow-Up Studies, Humans, Keratoconus/drug therapy, Keratoconus/physiopathology, Keratoconus/surgery, Keratoconus/therapy, Lasers, Excimer/therapeutic use, Male, Middle Aged, Photochemotherapy, Photorefractive Keratectomy, Photosensitizing Agents/therapeutic use, Prospective Studies, Refraction, Ocular/physiology, Riboflavin/therapeutic use, Treatment Outcome, Ultraviolet Rays, Visual Acuity/physiology, Young Adult
Pubmed
Web of science
Create date
01/10/2019 14:16
Last modification date
06/10/2019 5:26