Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.

Details

Serval ID
serval:BIB_C64A1880105A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Journal
Nature cell biology
Author(s)
Fumagalli F., Noack J., Bergmann T.J., Cebollero E., Pisoni G.B., Fasana E., Fregno I., Galli C., Loi M., Soldà T., D'Antuono R., Raimondi A., Jung M., Melnyk A., Schorr S., Schreiber A., Simonelli L., Varani L., Wilson-Zbinden C., Zerbe O., Hofmann K., Peter M., Quadroni M., Zimmermann R., Molinari M.
ISSN
1476-4679 (Electronic)
ISSN-L
1465-7392
Publication state
Published
Issued date
11/2016
Peer-reviewed
Oui
Volume
18
Number
11
Pages
1173-1184
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzymes to reduce the burden of misfolded proteins. On resolution of ER stress, ill-defined, selective autophagic programs remove excess ER components. Here we identify Sec62, a constituent of the translocon complex regulating protein import in the mammalian ER, as an ER-resident autophagy receptor. Sec62 intervenes during recovery from ER stress to selectively deliver ER components to the autolysosomal system for clearance in a series of events that we name recovER-phagy. Sec62 contains a conserved LC3-interacting region in the C-terminal cytosolic domain that is required for its function in recovER-phagy, but is dispensable for its function in the protein translocation machinery. Our results identify Sec62 as a critical molecular component in maintenance and recovery of ER homeostasis.

Keywords
Animals, Autophagy, Endoplasmic Reticulum/metabolism, Endoplasmic Reticulum Stress/physiology, Homeostasis, Humans, Membrane Transport Proteins/metabolism, Mice, Molecular Chaperones/metabolism, Protein Biosynthesis/physiology, Protein Transport/physiology, Unfolded Protein Response/physiology
Pubmed
Create date
01/12/2016 9:49
Last modification date
20/08/2019 15:41
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