Protection against chronic pyelonephritis in rats by suppression of acute suppuration: effect of colchicine and neutropenia

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_C624F99C8A0E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Protection against chronic pyelonephritis in rats by suppression of acute suppuration: effect of colchicine and neutropenia
Journal
Journal of Infectious Diseases
Author(s)
Bille  J., Glauser  M. P.
ISSN
0022-1899
Publication state
Published
Issued date
08/1982
Peer-reviewed
Oui
Volume
146
Number
2
Pages
220-6
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
licence nationale
Abstract
Previous experiments in rats have suggested that renal scarring after acute, obstructive pyelonephritis due to Escherichia coli results from parenchymal damage due to acute inflammation and suppuration. To assess the role of acute infiltration by polymorphonuclear leukocytes (PMNLs) in the pathogenesis of chronic pyelonephritis (CPN), rats were either treated with colchicine to depress leukocyte motility or rendered neutropenic with a single dose of cyclophosphamide. Colchicine given during acute pyelonephritis reduced kidney inflammation and protected against CPN two months later. Similarly, neutropenia reduced acute inflammation and protected against chronic parenchymal destruction and scarring. Protection against renal scarring in both colchicine-treated and neutropenic rats occurred despite higher renal bacterial counts during acute pyelonephritis. These experiments provide further evidence that CPN (renal scarring) results from kidney damage that occurs during early acute obstructive pyelonephritis. This damage appears to result from infiltration of the kidney by PMNLs rather than direct damage from bacterial infection.
Keywords
Abscess/etiology Animals Colchicine/pharmacology Cyclophosphamide/pharmacology Kidney/pathology Male Neutropenia Neutrophils/*physiology Pyelonephritis/*etiology/pathology Rats Rats, Inbred Strains
Pubmed
Web of science
Open Access
Yes
Create date
11/02/2008 12:39
Last modification date
01/10/2019 6:19
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