Pathogenicity of fibroblast- and lymphocyte-specific variants of minute virus of mice

Details

Serval ID
serval:BIB_C4577AF9965E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pathogenicity of fibroblast- and lymphocyte-specific variants of minute virus of mice
Journal
Journal of Virology
Author(s)
Kimsey  P. B., Engers  H. D., Hirt  B., Jongeneel  C. V.
ISSN
0022-538X (Print)
Publication state
Published
Issued date
07/1986
Volume
59
Number
1
Pages
8-13
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
We tested two strains of the minute virus of mice (MVM) for pathogenic effects and patterns of infection in laboratory mice. The two strains differ in their ability to infect differentiated cultured cells: the prototype virus, MVMp, infects only fibroblasts, while its variant, MVMi, is restricted to lymphocytes. We find that neither strain has any demonstrable effects on the T-cell function of mice infected as adults. In contrast, MVMi, but not MVMp, is able to induce a runting syndrome accompanied by mild immune deficiencies upon the infection of newborn mice. After neonatal infection, MVMi spreads to many organs, and the presence of viral replicative form DNA is evident in nucleic acid hybridization experiments. In contrast, replication of MVMp can be detected only by the seroconversion of infected animals. Newborn mice that grow abnormally as a result of MVMi infection also have low circulating antibody titers to the virus. This phenomenon may be a consequence of the lymphotropism of MVMi.
Keywords
Animals Animals, Newborn/microbiology Antibodies, Viral/biosynthesis Fibroblasts/microbiology Hypersensitivity, Delayed/immunology Immunity, Cellular Lymphocytes/microbiology Mice Minute virus of mice/growth & development/*pathogenicity Parvoviridae/*pathogenicity Tissue Distribution Virus Diseases/physiopathology
Pubmed
Web of science
Create date
24/01/2008 15:39
Last modification date
20/08/2019 15:39
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