Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_C423F727BB77
Type
Article: article from journal or magazin.
Publication sub-type
Minutes: analyse of a published work.
Collection
Publications
Title
Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.
Journal
Genome biology
Author(s)
Attardo G.M., Abd-Alla AMM, Acosta-Serrano A., Allen J.E., Bateta R., Benoit J.B., Bourtzis K., Caers J., Caljon G., Christensen M.B., Farrow D.W., Friedrich M., Hua-Van A., Jennings E.C., Larkin D.M., Lawson D., Lehane M.J., Lenis V.P., Lowy-Gallego E., Macharia R.W., Malacrida A.R., Marco H.G., Masiga D., Maslen G.L., Matetovici I., Meisel R.P., Meki I., Michalkova V., Miller W.J., Minx P., Mireji P.O., Ometto L., Parker A.G., Rio R., Rose C., Rosendale A.J., Rota-Stabelli O., Savini G., Schoofs L., Scolari F., Swain M.T., Takáč P., Tomlinson C., Tsiamis G., Van Den Abbeele J., Vigneron A., Wang J., Warren W.C., Waterhouse R.M., Weirauch M.T., Weiss B.L., Wilson R.K., Zhao X., Aksoy S.
ISSN
1474-760X (Electronic)
ISSN-L
1474-7596
Publication state
Published
Issued date
02/09/2019
Peer-reviewed
Oui
Volume
20
Number
1
Pages
187
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity.
Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges.
Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.
Keywords
Animals, DNA Transposable Elements/genetics, Drosophila melanogaster/genetics, Female, Gene Expression Regulation, Genes, Insect, Genes, X-Linked, Genome, Insect, Genomics, Geography, Insect Proteins/genetics, Insect Vectors/genetics, Male, Mutagenesis, Insertional/genetics, Phylogeny, Repetitive Sequences, Nucleic Acid/genetics, Sequence Homology, Amino Acid, Synteny/genetics, Trypanosoma/parasitology, Tsetse Flies/genetics, Wolbachia/genetics, Disease, Hematophagy, Lactation, Neglected, Symbiosis, Trypanosomiasis, Tsetse
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PP00P3_170664
Create date
05/09/2019 15:18
Last modification date
30/01/2020 7:20
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