Pattern of dopaminergic loss in the striatum of humans with MPTP induced parkinsonism

Details

Serval ID
serval:BIB_C421A95FD773
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pattern of dopaminergic loss in the striatum of humans with MPTP induced parkinsonism
Journal
Journal of Neurology, Neurosurgery and Psychiatry
Author(s)
Snow  B. J., Vingerhoets  F. J., Langston  J. W., Tetrud  J. W., Sossi  V., Calne  D. B.
ISSN
0022-3050 (Print)
Publication state
Published
Issued date
03/2000
Volume
68
Number
3
Pages
313-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
OBJECTIVES: To examine the distribution of striatal dopaminergic function in humans with parkinsonism induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) to determine if there is a caudate-putamen gradient as is seen in idiopathic Parkinson's disease. METHODS: We scanned nine humans exposed to MPTP with parkinsonism ranging from minimal to severe using [(18)F]fluorodopa (FD) and high resolution PET. The results were compared with those of 10 patients with Parkinson's disease and six normal subjects. RESULTS: In the MPTP group there was an equal degree of reduction of dopaminergic function in the caudate and putamen. This was different from the greater putaminal than caudate loss in Parkinson's disease (p<0.001). CONCLUSIONS: Parkinson's disease is not caused by transient exposure to MPTP.
Keywords
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*adverse effects Adult Corpus Striatum/*radionuclide imaging Female Humans Male Middle Aged Parkinson Disease, Secondary/etiology/*radionuclide imaging Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 13:49
Last modification date
20/08/2019 16:39
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