Association between melanism, physiology and behaviour: a role for the melanocortin system.

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State: Public
Version: Final published version
Serval ID
serval:BIB_C28BA5538A77
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Association between melanism, physiology and behaviour: a role for the melanocortin system.
Journal
European Journal of Pharmacology
Author(s)
Roulin A., Ducrest A.L.
ISSN
1879-0712 (Electronic)
ISSN-L
0014-2999
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
660
Number
1
Pages
226-233
Language
english
Abstract
The melanocortin system is implicated in the expression of many phenotypic traits. Activation of the melanocortin MC(1) receptor by melanocortin hormones induces the production of brown/black eumelanic pigments, while activation of the four other melanocortin receptors affects other physiological and behavioural functions including stress response, energy homeostasis, anti-inflammatory and sexual activity, aggressiveness and resistance to oxidative stress. We recently proposed the hypothesis that some melanocortin-physiological and -behavioural traits are correlated within individuals. This hypothesis predicts that the degree of eumelanin production may, in some cases, be associated with the regulation of glucocorticoids, immunity, resistance to oxidative stress, energy homeostasis, sexual activity, and aggressiveness. A review of the zoological literature and detailed experimental studies in a free-living population of barn owls (Tyto alba) showed that indeed melanic coloration is often correlated with the predicted physiological and behavioural traits. Support for predictions of the hypothesis that covariations between coloration and other phenotypic traits stem from pleiotropic effects of the melanocortin system raises a number of theoretical and empirical issues from evolutionary and pharmacological point of views.
Keywords
Animals, Behavior/drug effects, Humans, Melanocortins/genetics, Melanocortins/metabolism, Melanosis/genetics, Melanosis/metabolism, Phenotype, Physiological Processes/drug effects, Strigiformes/genetics, Strigiformes/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
17/11/2010 18:32
Last modification date
20/08/2019 16:37
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