Clinical growth rate of acoustic schwannomas: correlation with the growth fraction as defined by the monoclonal antibody ki-67.

Details

Serval ID
serval:BIB_C1423E87E531
Type
Article: article from journal or magazin.
Collection
Publications
Title
Clinical growth rate of acoustic schwannomas: correlation with the growth fraction as defined by the monoclonal antibody ki-67.
Journal
Skull Base Surgery
Author(s)
Lesser T.H., Janzer R.C., Kleihues P., Fisch U.
ISSN
1052-1453[print], 1052-1453[linking]
Publication state
Published
Issued date
1991
Volume
1
Number
1
Pages
11-15
Language
english
Abstract
The growth rate of acoustic tumors, although slow, varies widely. There may be a continuous spectrum or distinct groups of tumor growth rates. Clinical, audiologic, and conventional histologic tests have failed to shed any light on this problem. Modern immunohistochemical methods may stand a better chance. The Ki-67 monoclonal antibody stains proliferating cells and is used in this study to investigate the growth fraction of 13 skull base schwannomas. The acoustic tumors can be divided into two different growth groups, one with a rate five times the other. The literature is reviewed to see if this differentiation is borne out by the radiologic studies. Distinct growth rates have been reported: one very slow, taking 50 years to reach 1 cm in diameter, a second rate with a diameter increase of 0.2 cm/year, and a third rate five times the second, with a 1.0 cm increase in diameter per year. A fourth group growing at 2.5 cm/year is postulated, but these tumors cannot be followed for long radiologically, since symptoms demand surgical intervention. The clinical implications of these separate growth rates are discussed.
Pubmed
Web of science
Create date
20/10/2010 8:57
Last modification date
20/08/2019 15:35
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