Clinical growth rate of acoustic schwannomas: correlation with the growth fraction as defined by the monoclonal antibody ki-67.

Détails

ID Serval
serval:BIB_C1423E87E531
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clinical growth rate of acoustic schwannomas: correlation with the growth fraction as defined by the monoclonal antibody ki-67.
Périodique
Skull Base Surgery
Auteur(s)
Lesser T.H., Janzer R.C., Kleihues P., Fisch U.
ISSN
1052-1453[print], 1052-1453[linking]
Statut éditorial
Publié
Date de publication
1991
Volume
1
Numéro
1
Pages
11-15
Langue
anglais
Résumé
The growth rate of acoustic tumors, although slow, varies widely. There may be a continuous spectrum or distinct groups of tumor growth rates. Clinical, audiologic, and conventional histologic tests have failed to shed any light on this problem. Modern immunohistochemical methods may stand a better chance. The Ki-67 monoclonal antibody stains proliferating cells and is used in this study to investigate the growth fraction of 13 skull base schwannomas. The acoustic tumors can be divided into two different growth groups, one with a rate five times the other. The literature is reviewed to see if this differentiation is borne out by the radiologic studies. Distinct growth rates have been reported: one very slow, taking 50 years to reach 1 cm in diameter, a second rate with a diameter increase of 0.2 cm/year, and a third rate five times the second, with a 1.0 cm increase in diameter per year. A fourth group growing at 2.5 cm/year is postulated, but these tumors cannot be followed for long radiologically, since symptoms demand surgical intervention. The clinical implications of these separate growth rates are discussed.
Pubmed
Web of science
Création de la notice
20/10/2010 9:57
Dernière modification de la notice
03/03/2018 21:07
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