Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance.

Details

Serval ID
serval:BIB_BD9D7C31FF6D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance.
Journal
Nature Immunology
Author(s)
Makrigiannakis A., Zoumakis E., Kalantaridou S., Coutifaris C., Margioris A.N., Coukos G., Rice K.C., Gravanis A., Chrousos G.P.
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Publication state
Published
Issued date
2001
Volume
2
Number
11
Pages
1018-1024
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The semi-allograft embryo in the blastocyst stage implants itself in the endometrium, yet no immune rejection processes are activated. Embryonic trophoblast and maternal decidua produce corticotropin-releasing hormone (CRH) and express Fas ligand (FasL), a proapoptotic cytokine. We found that antalarmin, a CRH receptor type 1 antagonist, decreased FasL expression and promoted apoptosis of activated T lymphocytes, an effect which was potentiated by CRH and inhibited by antalarmin. Female rats treated with antalarmin showed a marked decrease in implantation sites and live embryos and diminished endometrial FasL expression. Embryos from mothers that lacked T cells or from syngeneic matings were not rejected when the mothers were given antalarmin. These findings suggested that locally produced CRH promotes implantation and maintenance of early pregnancy primarily by killing activated T cells.
Keywords
Animals, Antigens, CD95/physiology, Apoptosis/drug effects, Blastocyst/immunology, Blastocyst/physiology, Cells, Cultured/drug effects, Cells, Cultured/metabolism, Corticotropin-Releasing Hormone/pharmacology, Corticotropin-Releasing Hormone/physiology, Decidua/immunology, Embryo Implantation/drug effects, Embryo Implantation/physiology, Endometrium/immunology, Endometrium/metabolism, Fas Ligand Protein, Female, Gene Expression Regulation/drug effects, Histocompatibility, Humans, Inflammation, Litter Size/drug effects, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/genetics, Pregnancy, Pyrimidines/pharmacology, Pyrimidines/toxicity, Pyrroles/pharmacology, Pyrroles/toxicity, Rats, Rats, Inbred F344, Rats, Nude, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors, Receptors, Corticotropin-Releasing Hormone/physiology, T-Lymphocyte Subsets/drug effects, T-Lymphocyte Subsets/immunology, Trophoblasts/immunology
Pubmed
Web of science
Create date
14/10/2014 11:42
Last modification date
20/08/2019 15:31
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