Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Details

Serval ID
serval:BIB_BCBAFC9AB2BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Journal
Nature genetics
Author(s)
Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer TMF, Bacanu S.A., Bækvad-Hansen M., Beekman AFT, Bigdeli T.B., Binder E.B., Blackwood DRH, Bryois J., Buttenschøn H.N., Bybjerg-Grauholm J., Cai N., Castelao E., Christensen J.H., Clarke T.K., Coleman JIR, Colodro-Conde L., Couvy-Duchesne B., Craddock N., Crawford G.E., Crowley C.A., Dashti H.S., Davies G., Deary I.J., Degenhardt F., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Eriksson N., Escott-Price V., Kiadeh FHF, Finucane H.K., Forstner A.J., Frank J., Gaspar H.A., Gill M., Giusti-Rodríguez P., Goes F.S., Gordon S.D., Grove J., Hall L.S., Hannon E., Hansen C.S., Hansen T.F., Herms S., Hickie I.B., Hoffmann P., Homuth G., Horn C., Hottenga J.J., Hougaard D.M., Hu M., Hyde C.L., Ising M., Jansen R., Jin F., Jorgenson E., Knowles J.A., Kohane I.S., Kraft J., Kretzschmar W.W., Krogh J., Kutalik Z., Lane J.M., Li Y., Li Y., Lind P.A., Liu X., Lu L., MacIntyre D.J., MacKinnon D.F., Maier R.M., Maier W., Marchini J., Mbarek H., McGrath P., McGuffin P., Medland S.E., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Milani L., Mill J., Mondimore F.M., Montgomery G.W., Mostafavi S., Mullins N., Nauck M., Ng B., Nivard M.G., Nyholt D.R., O'Reilly P.F., Oskarsson H., Owen M.J., Painter J.N., Pedersen C.B., Pedersen M.G., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Posthuma D., Purcell S.M., Quiroz J.A., Qvist P., Rice J.P., Riley B.P., Rivera M., Saeed Mirza S., Saxena R., Schoevers R., Schulte E.C., Shen L., Shi J., Shyn S.I., Sigurdsson E., Sinnamon GBC, Smit J.H., Smith D.J., Stefansson H., Steinberg S., Stockmeier C.A., Streit F., Strohmaier J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Tian C., Traylor M., Treutlein J., Trubetskoy V., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Wang Y., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Witt S.H., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Baune B.T., Berger K., Boomsma D.I., Cichon S., Dannlowski U., de Geus ECJ, DePaulo J.R., Domenici E., Domschke K., Esko T., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Hinds D.A., Kendler K.S., Kloiber S., Lewis G., Li Q.S., Lucae S., Madden PFA, Magnusson P.K., Martin N.G., McIntosh A.M., Metspalu A., Mors O., Mortensen P.B., Müller-Myhsok B., Nordentoft M., Nöthen M.M., O'Donovan M.C., Paciga S.A., Pedersen N.L., Penninx BWJH, Perlis R.H., Porteous D.J., Potash J.B., Preisig M., Rietschel M., Schaefer C., Schulze T.G., Smoller J.W., Stefansson K., Tiemeier H., Uher R., Völzke H., Weissman M.M., Werge T., Winslow A.R., Lewis C.M., Levinson D.F., Breen G., Børglum A.D., Sullivan P.F.
Working group(s)
eQTLGen, 23andMe, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
50
Number
5
Pages
668-681
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
Keywords
Case-Control Studies, Depressive Disorder, Major/genetics, Female, Genetic Predisposition to Disease, Genome-Wide Association Study/methods, Humans, Male, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Schizophrenia/genetics
Pubmed
Web of science
Create date
01/05/2018 14:06
Last modification date
20/08/2019 16:30
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