Prior Stroke in PFO Patients Is Associated With Both PFO-Related and -Unrelated Factors.

Details

Serval ID
serval:BIB_BB8CF8970F76
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prior Stroke in PFO Patients Is Associated With Both PFO-Related and -Unrelated Factors.
Journal
Frontiers in neurology
Author(s)
Kahles T., Michel P., Hapfelmeier A., Eberli F.R., Zedde M., Thijs V., Kraemer M., Engelter S.T., Serena J., Weimar C., Mallmann A., Luft A., Hemelsoet D., Thaler D.E., Müller-Eichelberg A., De Pauw A., Sztajzel R., Armon C., Kent D.M., Meier B., Mattle H.P., Fischer U., Arnold M., Mono M.L., Nedeltchev K.
Working group(s)
International PFO Consortium NCT00859885
ISSN
1664-2295 (Print)
ISSN-L
1664-2295
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
11
Pages
503
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Background and Purpose: To identify factors associated with prior stroke at presentation in patients with cryptogenic stroke (CS) and patent foramen ovale (PFO). Methods: We studied cross-sectional data from the International PFO Consortium Study (NCT00859885). Patients with first-ever stroke and those with prior stroke at baseline were analyzed for an association with PFO-related (right-to-left shunt at rest, atrial septal aneurysm, deep venous thrombosis, pulmonary embolism, and Valsalva maneuver) and PFO-unrelated factors (age, gender, BMI, hypertension, diabetes mellitus, hypercholesterolemia, smoking, migraine, coronary artery disease, aortic plaque). A multivariable analysis was used to adjust effect estimation for confounding, e.g., owing to the age-dependent definition of study groups in this cross-sectional study design. Results: We identified 635 patients with first-ever and 53 patients with prior stroke. Age, BMI, hypertension, diabetes mellitus, hypercholesterolemia, coronary artery disease, and right-to-left shunt (RLS) at rest were significantly associated with prior stroke. Using a pre-specified multivariable logistic regression model, age (Odds Ratio 1.06), BMI (OR 1.06), hypercholesterolemia (OR 1.90) and RLS at rest (OR 1.88) were strongly associated with prior stroke.Based on these factors, we developed a nomogram to illustrate the strength of the relation of individual factors to prior stroke. Conclusion: In patients with CS and PFO, the likelihood of prior stroke is associated with both, PFO-related and PFO-unrelated factors.
Keywords
International PFO Consortium, PFO, cryptogenic stroke, hypercholesterolemia, patent foramen ovale, prior stroke, right-to-left shunt, risk factor
Pubmed
Web of science
Open Access
Yes
Create date
03/07/2020 17:25
Last modification date
09/12/2020 6:26
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