Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses.

Details

Serval ID
serval:BIB_BAB06A9E1569
Type
Article: article from journal or magazin.
Collection
Publications
Title
Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses.
Journal
Infection and Immunity
Author(s)
Bourreau E., Gardon J., Pradinaud R., Pascalis H., Prévot-Linguet G., Kariminia A., Pascal L.
ISSN
0019-9567 (Print)
ISSN-L
0019-9567
Publication state
Published
Issued date
2003
Volume
71
Number
4
Pages
2244-2246
Language
english
Abstract
Intralesional Th2 responses preceded the development of Th1 responses in localized cutaneous leishmaniasis due to Leishmania guyanensis. Although the number of parasites increased in Th2 lesions, no correlation was found between the levels of cytokine expression and the number of parasites. In contrast, the decreased number of parasites in Th1 lesions is negatively correlated to gamma interferon expression.
Keywords
Animals, Biopsy, Cytokines/biosynthesis, Humans, Leishmania/immunology, Leishmaniasis, Cutaneous/immunology, Leishmaniasis, Cutaneous/physiopathology, Skin/immunology, Skin/pathology, Th1 Cells/immunology, Th2 Cells/immunology
Pubmed
Web of science
Open Access
Yes
Create date
25/10/2011 15:10
Last modification date
20/08/2019 16:28
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