Function, evolution, and structure of J-domain proteins.

Details

Serval ID
serval:BIB_BA8B22317801
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Function, evolution, and structure of J-domain proteins.
Journal
Cell stress & chaperones
Author(s)
Kampinga H.H., Andreasson C., Barducci A., Cheetham M.E., Cyr D., Emanuelsson C., Genevaux P., Gestwicki J.E., Goloubinoff P., Huerta-Cepas J., Kirstein J., Liberek K., Mayer M.P., Nagata K., Nillegoda N.B., Pulido P., Ramos C., De Los Rios P., Rospert S., Rosenzweig R., Sahi C., Taipale M., Tomiczek B., Ushioda R., Young J.C., Zimmermann R., Zylicz A., Zylicz M., Craig E.A., Marszalek J.
ISSN
1466-1268 (Electronic)
ISSN-L
1355-8145
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
24
Number
1
Pages
7-15
Language
english
Notes
Publication types: Congress ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their facilitation of protein (re)folding, trafficking, remodeling, disaggregation, and degradation. Hsp70 machines are regulated by co-chaperones. J-domain containing proteins (JDPs) are the largest family of Hsp70 co-chaperones and play a determining role functionally specifying and directing Hsp70 functions. Many features of JDPs are not understood; however, a number of JDP experts gathered at a recent CSSI-sponsored workshop in Gdansk (Poland) to discuss various aspects of J-domain protein function, evolution, and structure. In this report, we present the main findings and the consensus reached to help direct future developments in the field of Hsp70 research.
Keywords
Animals, Disease, Evolution, Molecular, HSP70 Heat-Shock Proteins/chemistry, HSP70 Heat-Shock Proteins/classification, HSP70 Heat-Shock Proteins/metabolism, Humans, Protein Aggregates, Protein Domains, Protein Refolding, 8-stranded β-sandwich domain (SBDβ), Heat shock protein 70 (Hsp70), J-domain proteins (JDPs)
Pubmed
Web of science
Create date
04/01/2019 15:13
Last modification date
20/08/2019 16:28
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