Traitement hormonal de la ménopause : effets osseux et sur la composition corporelle [Menopausal hormone therapy. Effects on bone and body composition]

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Serval ID
serval:BIB_BA78B0DCA756
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Traitement hormonal de la ménopause : effets osseux et sur la composition corporelle [Menopausal hormone therapy. Effects on bone and body composition]
Journal
Revue medicale suisse
Author(s)
Papadakis G., Gonzalez Rodriguez E., Marques-Vidal P., Hans D., Vollenweider P., Waeber G., Lamy O.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
17/04/2019
Peer-reviewed
Oui
Volume
15
Number
647
Pages
836-839
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Changes occurring at menopause can be mitigated by prescribing menopausal hormone replacement therapy (HRT). Recent publications from the CoLaus/OsteoLaus cohorts provide important insights into the effects of HRT and after its discontinuation on bone and body composition. HRT has a beneficial effect on bone mineral density, bone microarchitecture and fracture prevention. The benefits persist after treatment discontinuation, but not beyond 2 to 5 years. The effect of HRT on body composition is more controversial. HRT reduces the accumulation of fat mass, mainly abdominal and visceral fat mass. This is important from the perspective of diabetes and cardiovascular disease prevention. However, the benefits seem to disappear immediately after discontinuation.
Keywords
Body Composition/drug effects, Bone Density, Bone and Bones, Estrogen Replacement Therapy, Female, Hormone Replacement Therapy, Humans, Menopause
Pubmed
Create date
28/04/2019 14:12
Last modification date
23/01/2020 6:19
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