Cutaneous leishmaniasis: progress towards a vaccine.

Details

Serval ID
serval:BIB_BA5960FD51AB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Cutaneous leishmaniasis: progress towards a vaccine.
Journal
Expert Review of Vaccines
Author(s)
Launois P., Tacchini-Cottier F., Kieny M.P.
ISSN
1744-8395 (Electronic)
ISSN-L
1476-0584
Publication state
Published
Issued date
2008
Volume
7
Number
8
Pages
1277-1287
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Leishmaniases are vector-borne diseases due to the protozoan parasite Leishmania . Since no prevention method is available and as current therapy is costly, often poorly tolerated and not always efficacious, the development of alternative therapies, including vaccines, constitutes the priority in the fight of Leishmania infection. This review focuses on recent advances in the development of vaccines against leishmaniasis, with emphasis on the cutaneous form. Indeed, the fact that recovery from leishmaniasis is associated with immunity against new infection provides a rational basis for the development of vaccination strategy against infection with Leishmania . Evidence from animal studies demonstrate that protection can be achieved following infection with live-attenuated Leishmania as well as through immunization with purified proteins or DNA vaccines. In addition, recent results have shown that immunization against the saliva of the insect vector could have synergistic effects with conventional vaccination. Finally, vaccination using dendritic cells was recently demonstrated as a possible tool for Leishmania vaccination.
Keywords
Animals, Dendritic Cells/immunology, Humans, Insects/immunology, Leishmania/immunology, Leishmaniasis Vaccines/immunology, Leishmaniasis, Cutaneous/prevention & control, Saliva/immunology, Vaccines, Attenuated/immunology, Vaccines, DNA/immunology, Vaccines, Subunit/immunology
Pubmed
Web of science
Create date
29/01/2009 23:14
Last modification date
20/08/2019 16:28
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