Patient and physician preferences: impact on treatment effectiveness

Details

Serval ID
serval:BIB_B9E2F1F2F350
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Patient and physician preferences: impact on treatment effectiveness
Journal
Epileptic Disord
Author(s)
Rheims S., Ryvlin P.
ISSN
1294-9361 (Print)
ISSN-L
1294-9361
Publication state
Published
Issued date
09/2012
Volume
14
Number
3
Pages
242-7
Language
english
Notes
Rheims, Sylvain
Ryvlin, Philippe
eng
France
Epileptic Disord. 2012 Sep;14(3):242-7. doi: 10.1684/epd.2012.0533.
Abstract
The greater reliability of randomised controlled trials (RCTs) over non-randomised studies to objectively assess efficacy and/or safety of new therapeutic interventions is one of the main paradigms which sustains the evidence-based decision process in clinical practice. This assumption is primarily based on the hypothesis that randomisation, and particularly blinding procedure, drastically reduces the potential bias related to the preferences of patients and physicians. However, from non-randomised studies to double-blind, placebo-controlled RCTs, the preferences of patients and physicians can impact the evaluation of treatment effectiveness. Both internal validity and external validity of RCTs are impacted by various biases related to patient and physician preferences. Thus, influence of patient and physician expectations on trial outcomes might be much less trivial than expected, both in open-label and double-blind, placebo-controlled, randomised trials. Accordingly, it might be interesting to systematically collect information about patient preferences before randomisation, using dedicated questionnaires, in order to be able to evaluate the impact of non-preferred allocation on trial results.
Keywords
Bias, *Double-Blind Method, Humans, Physicians, Randomized Controlled Trials as Topic, *Reproducibility of Results, Treatment Outcome
Pubmed
Create date
29/11/2018 12:37
Last modification date
20/08/2019 15:27
Usage data