Patient and physician preferences: impact on treatment effectiveness

Détails

ID Serval
serval:BIB_B9E2F1F2F350
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Patient and physician preferences: impact on treatment effectiveness
Périodique
Epileptic Disord
Auteur(s)
Rheims S., Ryvlin P.
ISSN
1294-9361 (Print)
ISSN-L
1294-9361
Statut éditorial
Publié
Date de publication
09/2012
Volume
14
Numéro
3
Pages
242-7
Langue
anglais
Notes
Rheims, Sylvain
Ryvlin, Philippe
eng
France
Epileptic Disord. 2012 Sep;14(3):242-7. doi: 10.1684/epd.2012.0533.
Résumé
The greater reliability of randomised controlled trials (RCTs) over non-randomised studies to objectively assess efficacy and/or safety of new therapeutic interventions is one of the main paradigms which sustains the evidence-based decision process in clinical practice. This assumption is primarily based on the hypothesis that randomisation, and particularly blinding procedure, drastically reduces the potential bias related to the preferences of patients and physicians. However, from non-randomised studies to double-blind, placebo-controlled RCTs, the preferences of patients and physicians can impact the evaluation of treatment effectiveness. Both internal validity and external validity of RCTs are impacted by various biases related to patient and physician preferences. Thus, influence of patient and physician expectations on trial outcomes might be much less trivial than expected, both in open-label and double-blind, placebo-controlled, randomised trials. Accordingly, it might be interesting to systematically collect information about patient preferences before randomisation, using dedicated questionnaires, in order to be able to evaluate the impact of non-preferred allocation on trial results.
Mots-clé
Bias, *Double-Blind Method, Humans, Physicians, Randomized Controlled Trials as Topic, *Reproducibility of Results, Treatment Outcome
Pubmed
Création de la notice
29/11/2018 12:37
Dernière modification de la notice
20/08/2019 15:27
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