Trajectory and predictors of quality of life in first episode psychotic mania.

Details

Ressource 1Download: BIB_B9D04D634EEC.P001.pdf (614.66 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_B9D04D634EEC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Trajectory and predictors of quality of life in first episode psychotic mania.
Journal
Journal of Affective Disorders
Author(s)
Oldis M., Murray G., Macneil C.A., Hasty M.K., Daglas R., Berk M., Conus P., Cotton S.M.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
195
Pages
148-155
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
BACKGROUND: Little is known about the trajectory of quality of life (QoL) following a first episode of psychotic mania in bipolar disorder (BD). This 18-month longitudinal study investigated the trajectory of QoL, and the influence of premorbid adjustment and symptoms on 18-month QoL in a cohort of young people experiencing a first episode of psychotic mania.
METHODS: As part of an overarching clinical trial, at baseline, sixty participants presenting with a first episode of psychotic mania (BD Type 1 - DSM-IV) completed symptomatic and functional assessments in addition to the Premorbid Adjustment Scale - General Subscale. Symptom measures were repeated at 18-month follow up. QoL was rated using the Quality of Life Scale (QLS) at designated time points.
RESULTS: Mean QLS scores at initial measurement (8 weeks) were 61% of the maximum possible score, increasing significantly to 70% at 12 months, and 71.2% at 18-month follow-up. Premorbid adjustment and 18-month depressive symptoms were significantly associated with QoL at 18-month follow-up.
LIMITATIONS: Study limitations include the small sample size, inclusion of participants with psychotic mania only, use of measures originally designed for use with schizophrenia spectrum disorders, and lack of premorbid or baseline measurement of QoL.
CONCLUSIONS: Results suggest that QoL can be maintained early in BD, and reinforce the importance of assertively treating depressive symptoms throughout the course of this disorder. The emergence of a link between premorbid adjustment and poorer QoL in this cohort highlights the importance of assessing facets of adjustment when planning psychological interventions.
Keywords
Adolescent, Adult, Bipolar Disorder/complications, Bipolar Disorder/psychology, Cohort Studies, Depression/complications, Depression/psychology, Diagnostic and Statistical Manual of Mental Disorders, Disease Progression, Employment, Female, Humans, Longitudinal Studies, Male, Predictive Value of Tests, Psychotic Disorders/complications, Psychotic Disorders/psychology, Quality of Life/psychology, Schizophrenic Psychology, Social Behavior, Socioeconomic Factors, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2016 16:52
Last modification date
20/08/2019 15:27
Usage data