New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.

Details

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State: Public
Version: author
Serval ID
serval:BIB_B96DE13CC3A4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.
Journal
Annual Review of Neuroscience
Author(s)
Stoop R., Hegoburu C., van den Burg E.
ISSN
1545-4126 (Electronic)
ISSN-L
0147-006X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
38
Pages
369-388
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In the present review, we discuss how the evolution of oxytocin and vasopressin from a single ancestor peptide after gene duplication has stimulated the development of the vertebrate social brain. Separate production sites became possible with a hypothalamic development, which, interestingly, is triggered by the same transcription factors that underlie the development of various subcortical regions where vasopressin and oxytocin receptors are adjacently expressed and which are connected by inhibitory circuits. The opposite modulation of their output by vasopressin and oxytocin could thus create a dynamic equilibrium for rapid responsiveness to external stimuli. At the level of the individual, nurturing early in life can long-lastingly program oxytocin signaling, maintaining a capability of learning and sensitivity to external stimuli that contributes to development of social behavior in adulthood. Oxytocin and vasopressin are thus important for the development of a vertebrate brain that supports bonding between individuals and building of an interactive community.
Keywords
Amygdala/metabolism, Amygdala/physiology, Animals, Brain/growth & development, Epigenesis, Genetic/genetics, Epigenesis, Genetic/physiology, Humans, Oxytocin/genetics, Oxytocin/metabolism, Receptors, Oxytocin/metabolism, Receptors, Vasopressin/metabolism, Social Behavior, Vasopressins/genetics, Vasopressins/metabolism
Pubmed
Web of science
Create date
24/08/2015 17:55
Last modification date
20/08/2019 16:27
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