SLE-Associated Defects Promote Altered T Cell Function.
Details
Serval ID
serval:BIB_B94359FDEE6B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
SLE-Associated Defects Promote Altered T Cell Function.
Journal
Critical reviews in immunology
ISSN
1040-8401 (Print)
ISSN-L
1040-8401
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
37
Number
1
Pages
39-58
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease linked to profound defects in the function and phenotype of T lymphocytes. Here, we describe abnormal signaling pathways that have been documented in T cells from patients with SLE and discuss how they impact gene expression and immune function, in order to understand how they contribute to disease development and progression.
Keywords
Animals, Humans, Lupus Erythematosus, Systemic/immunology, Lymphocyte Activation/immunology, Phenotype, Signal Transduction/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
15/02/2018 20:10
Last modification date
20/08/2019 15:27
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