Rational combinations of immunotherapy with radiotherapy in ovarian cancer.

Details

Serval ID
serval:BIB_B919A825548B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Rational combinations of immunotherapy with radiotherapy in ovarian cancer.
Journal
The Lancet. Oncology
Author(s)
Herrera F.G., Irving M., Kandalaft L.E., Coukos G.
ISSN
1474-5488 (Electronic)
ISSN-L
1470-2045
Publication state
Published
Issued date
08/2019
Peer-reviewed
Oui
Volume
20
Number
8
Pages
e417-e433
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Except for its use in palliative care, radiotherapy has been largely abandoned in the management of ovarian cancer because of the recognised efficacy and lower toxicity of systemic chemotherapy compared with radiotherapy. New data have emerged that show synergy of radiotherapy with immunotherapy to control or eradicate cancer. Different doses of hypofractionated radiotherapy have been shown to induce immunogenic cell death and in-situ vaccination in several tumour models. However, doses less than 2 Gy can also reprogramme the tumour microenvironment. This Series paper discusses the past and present use of radiotherapy for ovarian cancer, and the mechanisms by which radiotherapy can mobilise anticancer immunity. We provide emerging preclinical and clinical data for combining immunotherapy with radiotherapy for ovarian cancer treatment and offer a clinical development roadmap to guide the next generation of clinical trials for this combination strategy for this disease.
Keywords
Animals, Combined Modality Therapy/methods, Female, Humans, Immunotherapy/methods, Ovarian Neoplasms/drug therapy, Ovarian Neoplasms/radiotherapy, Radiotherapy/methods
Pubmed
Web of science
Create date
06/08/2019 16:11
Last modification date
07/07/2020 5:20
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