Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription.

Details

Serval ID
serval:BIB_B909C7A435AF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription.
Journal
Journal of Biological Chemistry
Author(s)
Hernandez N.
ISSN
0021-9258[print], 0021-9258[linking]
Publication state
Published
Issued date
2001
Volume
276
Number
29
Pages
26733-26736
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review Publication Status: ppublish
Abstract
The human small nuclear RNA (snRNA)1 genes, which encode snRNAs that are involved in RNA processing reactions such as mRNA splicing, serve as prototypes for a family of genes whose promoters are characterized by the presence of a proximal sequence element (PSE) and a distal sequence element (DSE). From a transcription point of view, this family of genes is highly interesting because all of its members have very similar promoters, even though some of them are transcribed by RNA polymerase (pol) II and others by pol III. As a result, the snRNA genes have served as a model system to explore how RNA polymerase specificity is determined and, in general, to compare the pol II and III transcription machineries. This has led to the concept that the pol II and III transcription machineries use common factors, the best known of which is the TATA box binding protein (TBP). In addition, the relative simplicity of these promoters has also made them an attractive system to study how transcriptional activators perform their function.
Keywords
Animals, DNA Polymerase III/metabolism, Humans, Promoter Regions, Genetic, RNA, Small Nuclear/genetics, Trans-Activators/metabolism, Transcription, Genetic
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2008 17:34
Last modification date
20/08/2019 16:27
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