Anomalies du transport rénal du sodium et sensibilité au sel de la pression artérielle [Abnormalities of renal sodium transport and blood pressure sensitivity to salt].

Details

Serval ID
serval:BIB_B8DE0612E09D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Anomalies du transport rénal du sodium et sensibilité au sel de la pression artérielle [Abnormalities of renal sodium transport and blood pressure sensitivity to salt].
Journal
Néphrologie et Thérapeutique
Author(s)
Burnier M.
ISSN
1769-7255 (Print)
ISSN-L
1769-7255
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
3 Suppl 2
Number
Suppl. 2
Pages
S94-S98
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
The blood pressure response to changes in dietary salt intake is highly variable among individuals and this heterogeneity results from the combined effects of genetic and environmental factors. In recent years, considerable progress has been made in our understanding of the pathogenic mechanisms leading to the development of salt-sensitive hypertension. Much information has come from the investigation of rare monogenic forms of salt-sensitive hypertension and has focused the attention on alterations of renal sodium handling occurring essentially in the distal segments of the nephron. There is now also extending experimental, clinical, genetic and epidemiological evidence suggesting that proximal tubular function is an important determinant of the blood pressure response to salt that would deserve a greater attention.
Keywords
Biological Transport, Blood Pressure/drug effects, Blood Pressure/physiology, Humans, Hypertension/etiology, Hypertension/physiopathology, Kidney/physiology, Kidney Tubules, Proximal/physiology, Kidney Tubules, Proximal/physiopathology, Sodium/physiology, Sodium, Dietary/adverse effects
Pubmed
Web of science
Create date
06/03/2008 11:33
Last modification date
20/08/2019 15:26
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