Photopolymerizable hydrogels for implants: Monte-Carlo modeling and experimental in vitro validation.

Details

Serval ID
serval:BIB_B816466D9F47
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Photopolymerizable hydrogels for implants: Monte-Carlo modeling and experimental in vitro validation.
Journal
Journal of Biomedical Optics
Author(s)
Schmocker A., Khoushabi A., Schizas C., Bourban P.E., Pioletti D.P., Moser C.
ISSN
1560-2281 (Electronic)
ISSN-L
1083-3668
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
19
Number
3
Pages
35004
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Photopolymerization is commonly used in a broad range of bioapplications, such as drug delivery, tissue engineering, and surgical implants, where liquid materials are injected and then hardened by means of illumination to create a solid polymer network. However, photopolymerization using a probe, e.g., needle guiding both the liquid and the curing illumination, has not been thoroughly investigated. We present a Monte Carlo model that takes into account the dynamic absorption and scattering parameters as well as solid-liquid boundaries of the photopolymer to yield the shape and volume of minimally invasively injected, photopolymerized hydrogels. In the first part of the article, our model is validated using a set of well-known poly(ethylene glycol) dimethacrylate hydrogels showing an excellent agreement between simulated and experimental volume-growth-rates. In the second part, in situ experimental results and simulations for photopolymerization in tissue cavities are presented. It was found that a cavity with a volume of 152  mm3 can be photopolymerized from the output of a 0.28-mm2 fiber by adding scattering lipid particles while only a volume of 38  mm3 (25%) was achieved without particles. The proposed model provides a simple and robust method to solve complex photopolymerization problems, where the dimension of the light source is much smaller than the volume of the photopolymerizable hydrogel.
Pubmed
Web of science
Open Access
Yes
Create date
05/08/2014 18:02
Last modification date
20/08/2019 15:26
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