Transient tone anomalies in very preterm infants: Association with term-equivalent brain magnetic resonance imaging and neurodevelopment at 18 months.

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Serval ID
serval:BIB_B815A29BF09D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transient tone anomalies in very preterm infants: Association with term-equivalent brain magnetic resonance imaging and neurodevelopment at 18 months.
Journal
Early human development
Author(s)
Brunner P., Schneider J., Borradori-Tolsa C., Bickle-Graz M., Hagmann P., Macherel M., Huppi P.S., Truttmann A.C.
ISSN
1872-6232 (Electronic)
ISSN-L
0378-3782
Publication state
Published
Issued date
04/2020
Peer-reviewed
Oui
Volume
143
Pages
104998
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Very preterm (VPT) infants are at risk for neurodevelopmental impairments and early clinical findings such as transient tone anomalies (TTA) might represent potential predictive indicators.
The aims of this study were to assess 1) the prevalence of TTA at 6 months corrected age in a population of VPT infants, 2) the association with term-equivalent age (TEA) brain MRI and 3) the neurodevelopmental outcome at 18 months corrected age.
A prospective case-control cohort of 103 VPT infants (<29 weeks of gestation) was followed up at 6 months and classified into TTA+ or TTA-. TTA+ was defined by the presence of ≥2 criteria among anomalies of posture, anomalies of tone and hyperreflexia.
Conventional and diffusion-weighted MRIs at TEA were analyzed according to a semi-quantitative MRI scoring system and apparent diffusion coefficients (ADC) and fractional anisotropy (FA) were measured in frontal, occipital white matter and posterior limb of the internal capsule (PLIC). Neurodevelopment was assessed at 18 months using Bayley-II scales (Psychomotor Developmental Index: PDI; Mental Developmental Index: MDI).
TTA+ infants represented 29.1% of the total population. They had: 1) significantly higher ADC values in 3 regions of interest (p < 0.001), 2) significant lower FA in the PLIC (p < 0.001), and 3) significant lower PDI score (p < 0.05). No differences were observed regarding MDI scores. Interaction of TTA by cerebellum score was related to lower MDI scores.
In VPT infants, TTA at 6 months and/or structural brain abnormality at TEA are associated with poorer neurodevelopmental outcome at 18 months.
Keywords
prematurity, transient tone anomalies, cerebral brain injury, MRI
Pubmed
Open Access
Yes
Create date
10/03/2020 15:31
Last modification date
20/01/2021 6:26
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